A Harvard researcher studying the evolution of drug resistance in cancer says that, in a few decades, “many, many cancers could be manageable.”“Many people are dying needlessly of cancer, and this research may offer a new strategy in that battle,” said Martin Nowak, a professor of mathematics and of biology and director of the Program for Evolutionary Dynamics. “One hundred years ago, many people died of bacterial infections. Now, we have treatment for such infections — those people don’t have to die. I believe we are approaching a similar point with cancer.”Nowak is one of several co-authors of a paper, published in Nature on June 28, that details how resistance to targeted drug therapy emerges in colorectal cancers and describes a multidrug approach to treatment that could make many cancers manageable, if not curable.The key, Nowak’s research suggests, is to change the way clinicians battle the disease.Physicians and researchers in recent years have increasingly turned to “targeted therapies” — drugs that combat cancer by interrupting its ability to grow and spread — rather than traditional chemotherapy, but such treatment is far from perfect. Most targeted therapies are effective for only a few months before the cancer evolves resistance to the drugs.The culprit in the colon cancer treatment examined in the Nature paper is the KRAS gene, which is responsible for producing a protein to regulate cell division. When activated, the gene helps cancer cells develop resistance to targeted-therapy drugs, effectively making the treatment useless.To better understand what role the KRAS gene plays in drug resistance, a team of researchers led by Bert Vogelstein, the Clayton Professor of Oncology and Pathology at the Johns Hopkins Kimmel Cancer Center, launched a study that began by testing patients to determine if the KRAS gene was activated in their tumors. Patients without an activated KRAS gene underwent a normal round of targeted therapy treatment, and the initial results — as expected — were successful. Tests performed after the treatment broke down, however, showed a surprising result: The KRAS gene had been activated.As part of the research, Vogelstein’s team analyzed a handful of mutations that can lead to the activation of the KRAS gene. To help interpret those results, they turned to Nowak’s team, including mathematicians Benjamin Allen, a postdoctoral fellow in mathematical biology, and Ivana Bozic, a postdoctoral fellow in mathematics.Analyzing the clinical results, Allen and Bozic were able to mathematically describe the exponential growth of the cancer and determine whether the mutation that led to drug resistance was pre-existing, or whether it occurred after treatment began. Their model was able to predict, with surprising accuracy, the window of time from when the drug is first administered to when resistance arises and the drug begins to fail.“By looking at their results mathematically, we were able to determine conclusively that the resistance was already there, so the therapy was doomed from the start,” Allen said. “That had been an unresolved question before this study. Clinicians were finding that these kinds of therapies typically don’t work for longer than six months, and our finding provides an explanation for why that failure occurs.”Put simply, Nowak said, the findings suggest that, of the billions of cancer cells that exist in a patient, only a tiny percentage — about one in a million — are resistant to drugs used in targeted therapy. When treatment starts, the nonresistant cells are wiped out. The few resistant cells, however, quickly repopulate the cancer, causing the treatment to fail.“Whether you have resistance prior to the start of treatment was one of the large, outstanding questions associated with this type of treatment,” Bozic said. “Our study offers a quantitative understanding of how resistance evolves, and shows that, because resistance is there at the start, the single-drug therapy won’t work.”The answer, Nowak said, is simple: Rather than the one drug used in targeted therapy, treatments must involve at least two drugs.Nowak isn’t new to such strategies. In 1995 he participated in a study, also published in Nature, that focused on the rapid evolution of drug resistance in HIV. The result of that study, he said, was the development of the drug “cocktail” many HIV-positive patients use to help manage the disease.Such a plan, however, isn’t without challenges.The treatment must be tailored to the patient, and must be based on the genetic makeup of the patient’s cancer. Perhaps even more importantly, Nowak said, the two drugs used simultaneously must not overlap: If a single mutation allows the cancer to become resistant to both drugs, the treatment will fail just as the single-drug therapy does.Nowak estimated that hundreds of drugs might be needed to address all the possible treatment variations. The challenge in the near term, he said, is to develop those drugs.“This will be the main avenue for research into cancer treatment, I think, for the next decade and beyond,” Nowak said. “As more and more drugs are developed for targeted therapy, I think we will see a revolution in the treatment of cancer.”
Three weeks ago, students crowded around TV screens, watching as votes trickled in from around the country.Some cheered. Some cried. Across campus, emotions ran high as one of the most divisive election seasons in American history drew to a close.Now, the country is starting to look forward and examine the implications of Donald Trump’s victory — and for University President Fr. John Jenkins, that means pondering what the election means for Notre Dame.Joseph Han, Chris Collins In an interview with The Observer on Thursday, Jenkins said he is considering inviting the President-elect to speak at this year’s Commencement ceremony.“I do think the elected leader of the nation should be listened to. And it would be good to have that person on the campus — whoever they are, whatever their views,” he said. “At the same time, the 2009 Commencement was a bit of a political circus, and I think I’m conscious that that day is for graduates and their parents — and I don’t want to make the focus something else.”Traditionally, the University has invited presidents to speak at graduation during their first year in White House. In 2009, President Barack Obama was the sixth president to deliver the Commencement address, following in the steps of Dwight Eisenhower, Jimmy Carter, Ronald Reagan, George H. W. Bush and George W. Bush.Jenkins said he plans to select a Commencement speaker sometime during the spring semester. Right now, he’s still weighing the different factors involved.“My concern a little bit is that, should the new president come, it may be even more of a circus,” he said. This election spurred levels political acrimony higher than Jenkins said he remembers in the past.“I think it’s fair to say the election reveals deep divides in this nation — divides on political views, on economic prospects, educational differences, differences in opportunities,” he said. “And they run deep in the country.”During this time, Jenkins said Notre Dame has a role as an educational institution to be a place of discussion that brings people together.“I think being president of Notre Dame gives me a certain soapbox. You can say things that people will pay attention to what you say because of that. I take that seriously,” he said. “I try to use that soapbox that I have as well as I can to serve those ideas and not kind of advance a personal agenda.”In a prayer service hosted six days after the election, Jenkins told undocumented students that the University would continue to support them, even if Trump were to rescind the Deferred Action for Childhood Arrivals (DACA) Program, as he promised to do during his campaign.The DACA Program was the result of an executive order issued by Obama and allows some undocumented immigrants who came to the U.S. as children to gain work authorization and, in many cases, financial aid to attend universities. Last week, Jenkins signed a public statement in support of DACA, joining more than 400 other college and university presidents.“These people were brought here as minors and are highly talented people, are valuable to this country,” Jenkins said. “So, if an administration would make changes, I would think trying to deport these talented young people would be among the most ill-advised moves they could make.”“If there should be an effort to do that, we would do everything we can to fight that, whatever way we can,” he added. “Not only for these young people who are Notre Dame students, but for the good of the nation.”In the past, the University has refused to give information on the immigration status of its students when asked by the state of Indiana. As a general policy, Notre Dame is guarded about giving any information about individual students to government agencies or other organizations, Jenkins said.But it’s difficult to plan for the future at this point in time, he added, because no one can do more than speculate what policies the Trump administration will institute after the inauguration ceremony in January.“I think it’s important at this stage to wait and to see and to listen,” he said.Jenkins said, in the past, elections and other current events have created divisions within the campus political environment. But he called the demonstrations in the days following Trump’s victory the largest he’s seen during his time as University president.“I think with the degree of animosity, the meanness of the rhetoric in the election, there was a lack of real discussion between the two opposing parties,” he said. “It does seem we have hit a peak or a sort of high point in terms of that animosity, that vitriol in public discussion.”Jenkins said it’s the first time since the election of Abraham Lincoln that riots broke out in cities across the U.S. in reaction to a presidential election; now, America faces the challenge of finding ways to foster constructive conversations.“The fact is we’re a democracy,” he said. “We can only move forward by addressing those divisions and trying to find a path forward that would address the concerns and needs of many people of this nation.”Tags: 2016 Election, 2017 commencement, DACA, Donald Trump
Image source: SCPASouth Carolina Ports Authority (SCPA) said in their latest announcement that Jim Newsome, SCPA president and CEO, R.D. James, Assistant Secretary of the U.S. Army for Civil Works, and other officials will gather on Friday, March 2, to celebrate the beginning of construction on the Charleston Harbor Deepening Project.Charleston Harbor Deepening to 52 feet will make Charleston the deepest harbor on the U.S. Coast, an advantage integral to the port’s ability to handle bigger container ships without tidal limitations and support growth and economic development of the entire state, said SCPA.Approximately eight years after efforts to deepen the Charleston Harbor began, this event will officially mark the beginning of construction on the project.According to the official statement, SC Governor Henry McMaster, U.S. Senator Lindsey Graham and LTG Todd T. Semonite, Chief of Engineers and Commanding General of the U.S. Army Corps of Engineers will also attend the ceremony.[mappress mapid=”24917″]
Jared Berggren went 3-for-3 from beyond the arc and was consistently open as Penn State’s defense got stuck in the paint, leaving the redshirt junior wide open for shot after shot. Berggren put up 13 points and grabbed six rebounds in the 65-55 Sunday afternoon.[/media-credit]Penn State men’s basketball head coach Patrick Chambers was afraid a familiar sight would appear at the Kohl Center Sunday against No. 15 Wisconsin.Despite the fact the Badgers hadn’t been shooting well as of late – and even worse at home than on the road – Chambers remained uneasy.And unfortunately for him, his premonition came true: The Badgers (20-7, 9-5 Big Ten) hit 11 of 22 three-pointers against the Nittany Lions (12-16, 4-11 Big Ten) Sunday in a 65-55 win.“I was scared for many reasons; they just lost to Michigan State, they hadn’t been shooting well and that’s like the perfect storm about to hit you,” Chambers said. “So you knew we could’ve been draped all over them and they were going to hit [shots] – and they did.“Eleven three’s in a game is just too many. You’re not going to win many games giving up 11.”Wisconsin picked itself up against the Nittany Lions after a convincing 69-55 loss last Thursday on the road against Michigan State. In turn, the Badgers, for the sixth year in a row, earned its 20th win of the season Sunday and reaffirmed its fourth-place position in the Big Ten standings.With four games remaining, Wisconsin rests a game and a half ahead of fifth-place Indiana and one game behind Michigan and Ohio State, which are tied for second. Two games separate the Badgers from the first-place Spartans.Guard Josh Gasser lead the scoring charge against PSU with 15 points while three other Badgers totaled double-digits as well. Jared Berggren added 13 while Jordan Taylor and Ryan Evans scored 11 apiece. Forward Mike Bruesewitz nabbed 12 rebounds while Evans plucked away nine more.Guard Tim Frazier scored 20 points for Penn State on 9-of-20 shooting while Jermaine Marshall put up 12 more in coming off the bench.Gasser, Taylor and Berggren all hit three three-pointers each for the Badgers, whose stream of treys really kicked into gear about halfway through the first period.Leading 12-9, after Taylor had previously sunk two shots from behind the perimeter, UW scored three-pointers on five consecutive possessions. Gasser hit three in a row, which were bookended by downtown lobs from Berggren and Ben Brust.Evans then hit a jumper – the sixth consecutive shot made for UW – and by the time it was all over, PSU’s three-point deficit inflated to 14 in just four minutes’ time. UW shot 48 percent in the first half compared to PSU’s 35.7 clip and was able to maintain that gap until halftime, leading 35-21.The Badgers’ offense buzzed with assertiveness all afternoon, and not just from the shooting standpoint. UW showcased sound ball movement in the first half and throughout the game, as assists accompanied nine of the Badgers 12 buckets in the opening period.For the game, 12 of 20 shots featured an assist for the Badgers.“After the Michigan State game we pushed the ball a little more,” Bruesewitz said. “We were successful that way. We were more aggressive and rolled with that.”However, shooting trends for the two teams reversed course in the second half. Wisconsin went on to hit 36.4 percent from the field, despite shooting 50 percent from three, while Penn State heated up and hit at a pace of 42.9 percent.That turnabout played quite a role in the Nittany Lions’ 13-0 run midway in the second period, dissolving its 20-point deficit to seven.Wisconsin committed two turnovers and watched six shots go wayward while Frazier and Jon Graham scored 11 of PSU’s 13 points during the run.That left Penn State just outside striking distance with under seven minutes remaining. But every time the Lions inched closer to the lead, Berggren arrived packing a three-pointer.Up by five with 5:30 left, Berggren hit his second trey of the game and hit his third about a minute later just after PSU again climbed within six.After that third and final 3-pointer, Penn State never came within nine points again.“Those two threes he hit were, to me, the difference because I thought we battled back and we did some good things,” Chambers said. “But they were daggers.”Wisconsin struggled to attack the rim all day, getting outscored 32-8 in the paint. But according to Wisconsin head coach Bo Ryan, Berggren was able to hit all three of his three-point attempts simply because the PSU defense overcompensated in defending the basket.“If you noticed, it was very difficult trying to get to the rim,” Ryan said. “So Jared was wide open because [Graham] was doing his job taking away the drives.”
AirDrop works by moving media through the cloud, via Apple’s iCloud. It then establishes a Wi-Fi Direct connection between the devices to move files between points. The use of iCloud allows AirDrop to know other users’ locations and theoretically makes file sharing easier. In contrast, Android Beam creates a connection between two devices and then transfers media through Bluetooth. Samsung’s S Beam is similar, but uses NFC to establish the connection and then uses Wi-Fi Direct. Samsung’s new Galaxy S4 has the ability to share content (such the same song on several different devices with one person acting as a DJ controller) in much the same way as AirDrop works. AirDrop can assure everyone of its users the same exact steps to expedite the activity. Tap the “Share” icon. AirDrop reveals available users nearby. Tap their avatar and the file is sent.This is where Apple’s ecosystem control delivers enhanced benefits to users. Two users wanting to transfer files will be able to open the same app, at the same time with the same results. While Android Beam (or the very similar S Beam) is present on all Android phones running version 4.0 Ice Cream Sandwich or higher, the interface between smartphones from different manufacturers does not lend itself to a common experience. Analysts estimate that at least 550 million devices are now running iOS 6. If Apple can just as quickly transition them to iOS 7, that’s a massive potential user base with which to AirDrop the latest viral video, family photo, office gossip, or hit song.The Ecosystem Giveth, The Ecosystem Taketh AwaySuccess will take time, if it is to happen at all. For AirDrop to work, users must have:iOS 7A newer iOS device – iPhone 5, iPad Mini, iPad (4th generation), iPod Touch (5th generation)An iCloud accountIn addition, users must be physically close to one another – although AirDrop transfers should work over a rather large area, somewhat like accessing Wi-Fi across different rooms in a house.Apple’s marketing for AirDrop focuses on photo sharing. Given the limitations of the service, at least at launch, this is no doubt a wise move to help prompt usage. Photo sharing services are hugely popular, after all. Security ConcernsUsers can choose to accept AirDrop files from their contacts, or from anyone with the appropriate device, or not at all.Security will be an obvious concern for most users. Apple states that AirDrop files are “fully encrypted.” Even still, it seems likely that someone masquerading as a contact – perhaps posing as a friend seated at the other end of a large college classroom – could send a malicious file that the recipient unwittingly accepts. There are no doubt other potential opportunities for ill intent.Wireless analyst Jack Gold said: “security will clearly be an issue, despite Apple always claiming it’s not. Things get hacked.” New Modes of SharingDespite these limitations, AirDrop possesses the potential to spur new forms of sharing digital content -and thus, potential new applications and even new businesses could spring from AirDrop. According to mobile market analyst Chetan Sharma, AirDrop should prove a “better way to share than text or email.” He also noted that AirDrop could enable other “communication modes” such as “airdropping a coupon instead of email them.”Again, the overarching concern, Sharma says, is that users must have very easy controls over what content they choose to accept, when and from whom. Otherwise, it becomes little more than spam. brian s hall Despite the persistent gnashing of teeth over Jony Ive’s re-making of iPhone’s apps, colors and iconography in the upcoming iOS 7, the real story is the many new features that Apple is incorporating into its highly lucrative mobile platform.Features such as wireless content sharing AirDrop could significantly impact user sharing behavior – at home, at work, and everywhere else. It’s not particularly revolutionary. Rather, AirDrop smartly leverages the core strengths of Apple’s unified ecosystem.AirDrop, long available on Macs, is being offered with Apple’s iOS 7 – the next version of the popular operating system for iPhone, iPad and iPod Touch. According to Apple, AirDrop lets users share photos, videos, web pages, contacts – “and anything else from any app with a Share button.”AirDrop sharing might include:A retailer “airdropping” a coupon into your Passbook app.Multi-player games with strangers on a train.Sharing meeting notes in an office setting.Guests sharing their favorite videos of the bride and groom during the ceremony.App developers might offer in-app freebies to customers who agree to “airdrop” a trial version of the app from their iPhone onto their friend’s iPhone. Advertisers may do the same.Families might share a variety of notes, lists, pictures and more across a plethora of “iDevices.”Ecosystem BenefitsThere are some very obvious caveats to all this, of course, despite the potential. Chiefly, in practice, AirDrop may ultimately deliver limited user value.After all, smartphone-to-smartphone sharing already exists, yet have you ever actually seen people ‘bump’ their smartphones? This Samsung commercial is clever, but do you know anyone who’s actually used this feature that was not on television? Related Posts Tags:#Apple#Instagram#iOS 7#iPad#iPhone#Vine AirDrop, however, has several advantages:It comes pre-installed on iOS 7.Every device with AirDrop will offer the same user experience.It is fully wireless – no physical bumping of devices necessary.Android Beam, Samsung’s S Beam, and apps like Bump, all require the devices touch each other, one-to-one, to initiate a file transfer. Even the more widely available NFC (near field communication) standards require devices physically touch one another or be in very close proximity, typically a few centimeters. AirDrop requires no touching and can transfer files one-to-many. What it Takes to Build a Highly Secure FinTech … Why IoT Apps are Eating Device Interfaces Role of Mobile App Analytics In-App Engagement The Rise and Rise of Mobile Payment Technology
Madusa Srinivas Rao, Arjuna award winner in 2004 for his achievements in the Paralympics, was sitting on his wheelchair outside Gate No. 14 of Nehru Stadium and pleading with the Delhi Police and other security officials to let him in.Hailing from Karim Nagar in Andhra Pradesh, Rao was wearing the eminent sportsperson card around his neck but he still had to face humiliation. The authorities had issued the card but it did not have the required security clearance sticker on it.”I have been waiting outside the stadium trying to speak to someone, telling them who I am. It has already been more than one hour and it is so difficult to move around on a wheel chair with so much rush around,” Rao said. Rao was the badminton champion in the Paralympics and he said that he had represented the country all over the globe.He had to struggle to get the card made in the first place as the Organising Committee did not give its immediate approval to his application.Rao repeatedly asked Harish Sharma from the OC, and only got the card after a lot of haggling.”They gave me a card after days of begging and pleading.I have come all the way from Andhra with my son. He was very keen and wanted to see the Games opening,” Rao said.When M AIL T ODAY checked with him after the start of the ceremony, he had finally managed to get into the stadium as some senior Delhi Police officers verified his claim and let him in after a long wait.advertisement”I finally got to see the Games, but the humiliation and trouble caused to a sportsperson can’t be repaired. The OC should also focus on the way they treat their athletes and learn to respect people like us who toil hard for the pride of the country,” Rao said.
Panelo: Duterte ‘angry’ with SEA Games hosting hassles SEA Games hosting troubles anger Duterte Hontiveros presses for security audit of national power grid Barroca finished with a game-high 22 points, including four free throws in the last 15 seconds, while Sangalang notched a double-double with 17 points and 15 rebounds.“It’s all about the mental toughness and maturity of this team. it’s a big win for us. Hopefully, we can sustain that on Wednesday,” Magnolia head coach Chito Victolero told reporters.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsRafi Reavis also posted a double-double with 16 points and 15 rebounds for Magnolia, which shoots for a commanding 3-1 advantage Wednesday night.“We still have a lot more to show. The important thing for us is to stick to our identity. We have to continue and play within our strengths which is our defense,” Victolero said. Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue MOST READ LATEST STORIES Don’t miss out on the latest news and information. Sports Related Videospowered by AdSparcRead Next PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss That’s exactly what the Hotshots did as they smothered the Beermen from the opening tip.And just like in Magnolia’s 99-94 win in the finals opener, San Miguel Beer struggled to make shots.The Beermen shot just 33 percent from the field. Even the usually efficient June Mar Fajardo had a hard time offensively, missing seven of his 11 attempts from the field. He had 17 points and 14 rebounds but also committed six turnovers with Reavis and Sangalang hounding him all game.ADVERTISEMENT Philippine Arena Interchange inaugurated Private companies step in to help SEA Games hosting Cayetano: Senate, Drilon to be blamed for SEA Games mess 200 young Filipinos join Schuman Cup football fest DA eyes importing ‘galunggong’ anew PBA IMAGESMANILA, Philippines—Magnolia clamped down on the defensive end to shut down San MIguel Beer, 86-82, and take a 2-1 series lead in the 2019 PBA Philippine Cup Finals Sunday night at Araneta Coliseum.Mark Barroca and Ian Sangalang came through for the Hotshots in the crucial moments to fend off the Beermen’s fourth quarter fightback.ADVERTISEMENT View comments
July 25, 2016 This hands-on workshop will give you the tools to authentically connect with an increasingly skeptical online audience. This story originally appeared on CNBC While AOL chief Tim Armstrong has been a key part of Verizon’s Yahoo pursuit, the driving force on the Verizon side is his boss, longtime Verizon executive Marni Walden.The career cell phone executive has been leading the company’s moves beyond telecommunications, particularly its expansion into video and advertising, and was instrumental in the acquisition of AOL.All the players in telecom talk about wanting to be more than just a “dumb pipe,” and Walden has been leading the charge at Verizon.”Making sure that you play in accessing the revenue opportunities above the connectivity is something we think a lot about,” she told Recode an interview late last year. “We can go do other things because of our strength in mobile.”Walden, 49, has spent her life in the wireless industry, since the days when cell phones were things that came in a briefcase. Her move to join the nascent mobile business was a far cry from her childhood growing up on a Wyoming cattle ranch.”When I was growing up, I wanted to be either a cowboy or a ballet dancer,” Walden told Bloomberg earlier this year. “But neither seemed like reasonable options.”Walden did show both an early knack for the cell phone business as well as significant staying power in rising to become one of the most powerful women in the industry.She served as both operating chief and marketing chief for Verizon Wireless after getting her start at the company as a regional executive for both it and predecessor AirTouch Cellular. She also worked earlier in her career at AT&T Wireless and McCaw Cellular, among other cell phone companies.These days, though, Walden is in charge of new business opportunities for Verizon. Some of those are things involve the cellular business, such as connected cars, but much of Walden’s work has been in areas new to both her and Verizon.”People are surprised about Verizon getting into the content space,” Walden told Recode last year. “I think that’s really important to bring eyeballs and audience. Our media business will play a much more significant role in the Verizon of the future.”It hasn’t all been easy going for Verizon, particularly its efforts in video programming. The company launched a mobile video service known as Go90 last year, but it remains a relative nonentity.Rather than boasting well-known shows, big sports deals or original programming, Go90 has relied on short clips it hopes will appeal to the YouTube generation. In that vein, Verizon recently hired former YouTube executive Ivana Kirkbride to be Go90’s chief content officer.Probably the biggest thing going for Go90 is that it can undercut rivals on price. Not only is there no price for subscribing, but for Verizon Wireless customers, using the service doesn’t even count against their data cap.While watching a few movies on Netflix or binge-watching TV shows on Hulu can quickly eat through a customer’s plan, Verizon users are free to watch as much Go90 as they like. Verizon hasn’t said just how many people are actually taking the company up on the offer, but net neutrality advocates hate the way Verizon is prioritizing its own service.Walden made it clear in last year’s interview that Verizon might need to make more acquisitions — possibly including Yahoo — to reach its ambitions in the media and content realm.”We didn’t get into the media company business just to be a single-digit market share player,” Walden said. “We have much bigger aspirations of how we want to grow that business. Some can happen because of the scale Verizon brings, but we will continue to look at how we can scale and be a meaningful player from a double-digit market share, and by market share, I think about revenue. We definitely will look to build this business.”– By Ina Fried, Recode.net. 4 min read Free Workshop | August 28: Get Better Engagement and Build Trust With Customers Now Enroll Now for Free