Temple Of The Dog returned to the Tower Theatre in Philadelphia last night for their second show together on their first-ever tour. The 90’s grunge supergroup features Chris Cornell of Soundgarden and Stone Gossard, Jeff Ament, Mike McCready, and Matt Cameron of Pearl Jam. The setlist was almost exactly the same as the first night, featuring plenty of originals from their self-titled debut album, their recently recently released EP, Temple of the Dog pre-cursor Mother Love Bone, and a few choice covers by David Bowie, Led Zeppelin, Black Sabbath and The Cure, and more. To make the night unique, Temple of the Dog threw in some extra surprises, including a cover of Mad Season‘s “River Of Deceit.” Watch the video below via YouTube user mfc172:The night’s real highlight, in terms of rarity, was the debut of a never-before-heard Chris Cornell original “Missing.” As Cornell explained prior to the debut, the song dates back to the early 90s, around the time when he wrote “Spoonman” and “Seasons.” Watch fan-shot video of the performance below via YouTube user Jim Powers:You can see the full setlist below via setlist.fm. Temple Of The Dog continues their reunion tour continues tomorrow at Madison Square Garden in New York City.
Scientists looking to nature for inspiration in solving humanity’s problems gathered at Harvard Medical School (HMS) on Friday to learn how robotics is helping to improve medical care.Participants in the Wyss Institute for Biologically Inspired Engineering’s annual symposium, called “Noise and Rhythm: Harnessing Complexity in Medicine and Robotics,” heard about how advances in the field are improving artificial limbs, about how other devices are teaching injured people to walk, about manufacturing and control of small flying robots, and about advances in “swarm intelligence” controlling bunches of machines.Wyss Director Donald Ingber, the Judah Folkman Professor of Vascular Biology at HMS and professor of bioengineering at the School of Engineering and Applied Sciences, introduced the daylong event, which took place at HMS’s New Research Building.Ingber said the Wyss has come a long way in the three-and-a-half years since it began, and today has 300 full-time staff members, 100,000 square feet of space, 180 patents, 20 to 25 industry collaborations, and two clinical trials about to begin.Three speakers in the morning addressed the complexity of nature’s rhythms, highlighting research that explored irregularities in heartbeat, in nerve signaling, and in babies’ breathing while asleep. Ary Goldberger, a core faculty member at the Wyss and professor of medicine at HMS and at Harvard-affiliated Beth Israel Deaconess Medical Center, said that the traditional view of medicine has been that health is a steady state disrupted by illness. Once the illness is overcome, the body returns to its normal state. The more researchers learn, however, the more they understand that health is not a simple steady state, but is complex and dynamic, which is an important lesson in understanding robotic design.Michael Goldfarb, Flowers Professor of Mechanical Engineering at Vanderbilt University and director of the Vanderbilt Center for Intelligent Mechatronics, described a new, powered, artificial leg that improves on current models that function passively. Passive prosthetics are hinged at the knee and work using the movement of a wearer’s upper leg to swing the lower leg into place.The passive legs, Goldfarb said, have several drawbacks, including the extra energy it requires to move. People using them walk slower and have trouble in places, such as on inclines and stairs, where those who have both legs can use muscle power to help.An answer to the problem was developed in Goldfarb’s lab, in the form of a powered prosthetic that provides a push from the forefoot with each step and that has been shown to improve the ability of amputees to climb and descend stairs and handle inclines.Arthur Kuo, professor of mechanical and biomedical engineering at the University of Michigan, spoke about how scientists are learning from nature about new ways to power mobile devices. Batteries are usually bulky and heavy, making up as much as 20 percent of the weight of prosthetic devices, while human body fat is much more energy-dense. Even a lean person has enough fat to walk for many kilometers, he said.“Is there some way to use fat to provide power in a useful way for mobile devices?” Kuo asked.Kuo investigated the human walking motion to see if it could provide an energy source. Energy is lost with every step due to collision forces occurring at the ankle and knee when the heel hits the ground. This understanding has allowed development of devices, one at the knee and one underfoot, that can generate power through the normal walking motion and that could power prosthetics.
A Harvard researcher studying the evolution of drug resistance in cancer says that, in a few decades, “many, many cancers could be manageable.”“Many people are dying needlessly of cancer, and this research may offer a new strategy in that battle,” said Martin Nowak, a professor of mathematics and of biology and director of the Program for Evolutionary Dynamics. “One hundred years ago, many people died of bacterial infections. Now, we have treatment for such infections — those people don’t have to die. I believe we are approaching a similar point with cancer.”Nowak is one of several co-authors of a paper, published in Nature on June 28, that details how resistance to targeted drug therapy emerges in colorectal cancers and describes a multidrug approach to treatment that could make many cancers manageable, if not curable.The key, Nowak’s research suggests, is to change the way clinicians battle the disease.Physicians and researchers in recent years have increasingly turned to “targeted therapies” — drugs that combat cancer by interrupting its ability to grow and spread — rather than traditional chemotherapy, but such treatment is far from perfect. Most targeted therapies are effective for only a few months before the cancer evolves resistance to the drugs.The culprit in the colon cancer treatment examined in the Nature paper is the KRAS gene, which is responsible for producing a protein to regulate cell division. When activated, the gene helps cancer cells develop resistance to targeted-therapy drugs, effectively making the treatment useless.To better understand what role the KRAS gene plays in drug resistance, a team of researchers led by Bert Vogelstein, the Clayton Professor of Oncology and Pathology at the Johns Hopkins Kimmel Cancer Center, launched a study that began by testing patients to determine if the KRAS gene was activated in their tumors. Patients without an activated KRAS gene underwent a normal round of targeted therapy treatment, and the initial results — as expected — were successful. Tests performed after the treatment broke down, however, showed a surprising result: The KRAS gene had been activated.As part of the research, Vogelstein’s team analyzed a handful of mutations that can lead to the activation of the KRAS gene. To help interpret those results, they turned to Nowak’s team, including mathematicians Benjamin Allen, a postdoctoral fellow in mathematical biology, and Ivana Bozic, a postdoctoral fellow in mathematics.Analyzing the clinical results, Allen and Bozic were able to mathematically describe the exponential growth of the cancer and determine whether the mutation that led to drug resistance was pre-existing, or whether it occurred after treatment began. Their model was able to predict, with surprising accuracy, the window of time from when the drug is first administered to when resistance arises and the drug begins to fail.“By looking at their results mathematically, we were able to determine conclusively that the resistance was already there, so the therapy was doomed from the start,” Allen said. “That had been an unresolved question before this study. Clinicians were finding that these kinds of therapies typically don’t work for longer than six months, and our finding provides an explanation for why that failure occurs.”Put simply, Nowak said, the findings suggest that, of the billions of cancer cells that exist in a patient, only a tiny percentage — about one in a million — are resistant to drugs used in targeted therapy. When treatment starts, the nonresistant cells are wiped out. The few resistant cells, however, quickly repopulate the cancer, causing the treatment to fail.“Whether you have resistance prior to the start of treatment was one of the large, outstanding questions associated with this type of treatment,” Bozic said. “Our study offers a quantitative understanding of how resistance evolves, and shows that, because resistance is there at the start, the single-drug therapy won’t work.”The answer, Nowak said, is simple: Rather than the one drug used in targeted therapy, treatments must involve at least two drugs.Nowak isn’t new to such strategies. In 1995 he participated in a study, also published in Nature, that focused on the rapid evolution of drug resistance in HIV. The result of that study, he said, was the development of the drug “cocktail” many HIV-positive patients use to help manage the disease.Such a plan, however, isn’t without challenges.The treatment must be tailored to the patient, and must be based on the genetic makeup of the patient’s cancer. Perhaps even more importantly, Nowak said, the two drugs used simultaneously must not overlap: If a single mutation allows the cancer to become resistant to both drugs, the treatment will fail just as the single-drug therapy does.Nowak estimated that hundreds of drugs might be needed to address all the possible treatment variations. The challenge in the near term, he said, is to develop those drugs.“This will be the main avenue for research into cancer treatment, I think, for the next decade and beyond,” Nowak said. “As more and more drugs are developed for targeted therapy, I think we will see a revolution in the treatment of cancer.”
Poison in Arctic and human cost of ‘clean’ energy Hydroelectric energy may be more damaging to northern ecosystems than climate change Instead, distant parts of the globe would feel the effects. The ocean is not a bathtub, but Greenland’s meltwater would have to go somewhere.That scenario, described by Mitrovica in his talk at the Geological Lecture Hall, would also apply to glaciers and the other major ice sheet scientists say is endangered by climate change: the West Antarctic. In that case, the falling sea level would be near Antarctica and the highest rise would be offshore of Washington, D.C.“The moral is what you’re going to see depends on where you are,” Mitrovica said.Mitrovica’s talk, “Ancient Eclipses, Roman Fish Tanks, and the Enigma of Global Sea Level Rise,” examined the dynamics of sea level rise and debunked the arguments of climate-change deniers.Using levels inferred from Roman fish holding tanks and records of ancient eclipses, scientists have determined that average sea level rise in the last century has been the most significant in 2,000 years. Further, Mitrovica said, it appears that the rise over the last decade has been the most dramatic in a century.Recent research conducted at Harvard fine-tuned estimates of the average global sea level rise across the 20th century, pegging it at about 1.2 millimeters a year. That was a downward revision from the previously accepted figure of between 1.5 and 1.8 millimeters a year. The revision isn’t good news, however, because it means sea level has been rising faster in more recent years. Satellite measurements of 3.4 millimeters annually in recent years appear to be correct, Mitrovica said.One important result is that flood zones are rapidly moving inland. Areas that used to be endangered by 100-year floods are now in the 20-year flood zone.The sea level picture isn’t all bad news, Mitrovica said. Some have worried that the West Antarctic Ice Sheet could undergo catastrophic collapse, raising the sea level enough to inundate many cities. The fear emerged because the bedrock underneath the sheet is below sea level. If seawater were to penetrate and lift the sheet, the thinking goes, its collapse could happen fast.The gravitational effect of the ice, however, alters that scenario. As the ice melts, the nearby sea level will fall, reducing the risk of catastrophic collapse. Still, a single bright spot doesn’t change the worry that sea level could rise a meter over the next century, Mitrovica said.“We are changing this planet and sea level [rise] will accelerate. One meter more of sea level won’t appear evenly. It depends on which ice sheet melts.” Funny thing about sea level rise: Sometimes it falls.While many of us think of the oceans as a bathtub in which the level rises evenly as it fills with meltwater from glaciers and ice sheets, the reality is not so neat, Professor of Geophysics Jerry Mitrovica said Monday.The ocean, it turns out, is not a bathtub, and the ice melting thanks to climate change is not a spigot. That ice is vast, however. The Greenland Ice Sheet alone is more than a mile deep and extends beyond 1,000 miles.The ice exerts a gravitational pull, as do all things with mass. As it melts, the pull relaxes, causing the nearby sea level to drop even as meltwater pours into the ocean.“Sea level after a melting doesn’t remotely resemble a bathtub,” Mitrovica said.On a global scale “nearby” can cover a lot of territory, he pointed out, extending more than 1,000 miles. In other words, were Greenland’s massive ice sheet to collapse, nearby regions such as Iceland and coastal Europe would not be inundated. Related
The stage adaptation of the classic 1998 film Bull Durham, which will play a previously reported limited engagement at the Alliance Theatre in Atlanta this fall, is eyeing a move to the Great White Way. Book writer Ron Shelton told newsobserver.com: “We run that for five weeks, then if all goes well, we’re on Broadway next spring.” Directed by Kip Fagan, the tuner will also feature music and lyrics by Susan Werner. No word yet on casting. Shelton, who received an Oscar nomination for the Bull Durham screenplay and also helmed the film, revealed about Werner’s work: “I’m crazy about the music she’s written, it’s very un-Broadway. It’s real roadhouse. You pull over to the side of the road, back in the day, in North Carolina or Mississippi, this is the music that might be going on.” View Comments Bull Durham is inspired by Shelton’s time on and off the Minor League Baseball field. The musical tells the story of veteran catcher “Crash” Davis who is brought to the Durham Bulls to prepare rookie pitcher Ebby Calvin “Nuke” LaLoosh for the majors. Annie Savoy, the muse of the Bulls, has a tough choice to make – each season she converts one player from an also-ran to an all-star by sharing her wisdom and her bed. The love triangle heats up, as each character fights with their own wants and hopes for what the future holds.
The Vermont Irene Flood Relief Fund is awarding $86,500 this week in new grants to 48 small business impacted by flooding. To date, the Fund has granted $289,000 to 167 businesses located in 10 of Vermont’s 14 counties. The Fund has received 239 requests for assistance, with applicants estimating losses totaling in excess of $25 million ‘ with insurance covering only an estimated 20% of the damage.The Fund has received more than 400 donations from individuals, businesses, and foundations from around the United States and even overseas. Two recent grants from the Argosy Foundation ($50,000) and the Newman’s Own Foundation ($30,000) have boosted the Fund’s capacity to continue making grants. ‘The outpouring of support to help the business community recover has been incredible,’ notes Kate Paine, Executive Director of the Women’s Business Owners Network, who serves on the Fund’s seven-member application review panel. ‘It really speaks to the special nature of our state when people respond so willingly with financial resources and as volunteers to help out in times of great need.’Charlie Wilson, Chairman of the Vermont Alliance of Independent Country Stores, has also helped review applications to the Fund. ‘It has been both incredibly rewarding to be able to help direct money as an outright grant to so many business owners in need of relief, and frustrating that we couldn’t give them all more,’ he notes. ‘I hope we’ve been able to help, even in a small way, these businesses get back on their feet.’ ‘It has been absolutely heart-wrenching to learn about the nature and extent of the flood damage to the small business community,’ says Hal Cohen, Executive Director of the Central Vermont Community Action Council. Cohen’s agency is the fiscal agent for the fund and he also serves on the application review panel. ‘It’s clear that we face a long road to recovery, but I know Vermonters will continue to help in whatever ways they can until our communities are made whole again.’About the Vermont Irene Flood Relief Fund (www.vtirenefund.org(link is external)) Founded in August 2011 by Montpelier resident Todd Bailey for the purpose of raising money to support small businesses damaged by flooding from Tropical Storm Irene. After a grant application review process, all funds raised will be directly awarded to Vermont businesses in their efforts to rebuild from damage or losses sustained. Grant applications can be obtained online at www.vtirenefund.org(link is external) or by calling 802-552-3449. Fiscal Agent: Central Vermont Community Action Council Founded in 1965, Central Vermont Community Action Council (CVCAC) helps people achieve economic sufficiency with dignity through individual and family development. CVCAC is part of the nationwide network of Community Action Agencies; a 501(c)3 nonprofit agency and a Community Development Corporation. The organization serves over 18,000 low-income Vermonters each year in Washington, Orange and Lamoille counties and offers a number of statewide programs. www.cvcac.org(link is external) Member of the VT Irene Flood Relief Fund Advisory Committee: · Todd Bailey ‘ Associate at KSE Partners (www.ksepartners.com(link is external))· Andrew Brewer, Owner, Onion River Sports· Hal Cohen, Executive Director, Central Vermont Community Action Council· Andrea Cohen, Executive Director, Vermont Businesses for Social Responsibility· Kate Paine, Executive Director, Women Business Owners Network and Principal, Kate Paine Associates· Shawn Shouldice, Principal, Capital Connections, LLC· Charlie Wilson, Chairman, Vermont Alliance of Independent Country Stores· Kevin Wiberg, Fund Administrator,
I’ve been meaning to pay a visit to NoDa Brewing for a couple of years now, but could never seem to make it to the Charlotte, NC, brewery in person.They have a small, 15-barrel brew house that’s been gaining a lot of attention for their weekly one-off experimental brews and wicked-good IPA’s. Finally, like a dream come true, NoDa Brewing came to me. Sort of.I was in my local beer shop and found a four pack of Hop, Drop ‘n Roll — NoDa’s flagship IPA that’s getting ridiculously good views.I bought a four pack of tall boys and worked my way through them fast, enjoying the citrusy hop bomb that NoDa has created.Hop Drop ‘n Roll is one of the better examples of an IPA you can find in the South, coming out of a tiny, hyper-local brewery that most of us living outside of their small distribution area wouldn’t be able to experience if it weren’t for one of the greatest inventions of modern time: The mobile canning system.Imagine a van that drives around the country, visiting small breweries who make amazing beer, like NoDa, but don’t have the space or capital to buy a canning line of their own. The van pulls up with the canning line in tow, and “Bob’s your uncle”—that tiny brewery gets to can a small batch of their beer. Asheville’s Pisgah Brewing got to can a run of their uber-popular Pisgah Pale thanks to a mobile canning system. Devils Backbone, Hardywood Park, and Wild Wolf have all used mobile canning systems in the past. Even tiny nano-breweries working on two-barrel systems have been able to get in on the caning action because of these mobile canning systems.The breweries are still hyper local, and their distribution is still small, but with one-off canning runs, they have a chance to get their beer into the hands of more people. People like you and people like me. So keep an eye out for unfamiliar labels in your local beer shop: The cans are coming.
By Dialogo July 15, 2010 With euphoric shouts, a caravan kilometers long, and flags waving, Uruguay welcomed its team home as champions, after they finished the South African World Cup in fourth place. Thousands of Uruguayans spent hours in the streets to wait for the passage of the bus carrying the players, defying the cold temperatures in the capital, Montevideo. The celebration started at noon, when the athletes left their training center, and ended in the evening, at the Congress, where the team was applauded by tens of thousands and was celebrated by the government, led by President José Mujica. Uruguay was one of the surprises of the competition, finishing the initial round in first place in its group and then advancing to the semifinals in an emotional game against Ghana, decided by penalty kicks. The team ended in fourth place after losing to Germany with a score of 3 to 2. From the large stage set up at the Congress entrance, the players and coach Oscar Tabárez greeted and thanked the crowd, who were celebrating Uruguay’s best World Cup finish in four decades. “We are moved, but most of all thankful, very thankful. These young men deserve recognition, but this surpasses anything we could imagine; there are no words to describe what we have witnessed today,” said Tabárez to the cheering crowd that shouted his name. The Uruguayan president, who has a close relationship with the players, reiterated his gratitude for the way that the “sky-blue” team united the entire country.
By Dialogo October 13, 2015 I like El Tiempo because the way it reveals news or productsI hope it continues to go very well for them Great. In other words, the app works Environmental damages The goal of the 70,000 Colombian National Army Troops estimated to be guarding the country’s oil pipeline structure is to shield oil infrastructure facilities from terrorist groups, protect the environment, and capture perpetrators of attacks. Attacks decrease, but fight continues “On the one hand, we have the fuel stolen by puncturing pipelines and installing illegal valves, which is used in many cases to process cocaine base,” Gen. Jiménez said. “And then, we have attacks on the economic infrastructure of the country (oil pipelines, oil tank trucks on the roads, electrical towers, and mining camps), which are used to exert pressure on the government.” Within 12 hours, Soldiers cleared the attacked area and secured the zone, allowing workers to commence making repairs. The Army ensured Troops, Cenit personnel, and environmental experts were safe to perform their emergency response tasks. Most recently, the Ministry of Defense activated the Sword of Honor campaign response after a major June 21 terrorist attack where alleged FARC operatives detonated explosives on the Trans-Andean Oil Pipeline, spilling 10,000 barrels of oil in the southern department of Nariño. The attack caused massive environmental damage; oil flowing into the Pianulpí gorge fed into the Güiza and Mira rivers, feeding into the municipality of Tumaco’s aqueduct and emptying directly into the Pacific Ocean. As a result, about 160,000 residents were without potable water for 18 days. The Ministry of the Environment also plans on creating an Environmental Liability Fund to study the effects and accurately determine the best solutions for Colombia, particularly with regard to environmental damages linked to terrorism. negative effects on reproduction and propagation in flora and fauna; For example, in the case of the June 21 oil spill in Tumaco, the Maritime and Coastal Investigation Institute (INVEMAR) reported on August 24 that some of the effects included: decrease in resistance to disease or increases in infections in species due to their absorption of particular quantities of petroleum; Under the Sword of Honor campaign, the Colombian Armed Forces are working with government entities and private businesses to protect the country’s oil-producing infrastructure from attacks that harm companies, the economy, and the environment, perpetrated by the Revolutionary Armed Forces of Colombia (FARC) and the National Liberation Army (ELN). The INVEMAR study also determined that the mangrove swamps, the habitat for a large number of plant and animal species, was one of the marine ecosystems most effected by the spill: “In this part of the Colombian Pacific coast, there are nine species of mangrove that form dense forests that cover approximately 138,320 hectares, or 40% of the national lands.” For years, the Armed Forces and civilian authorities have battled outlaw groups like the FARC and ELN who attack oil pipelines, in particular the country’s oldest: the Trans-Andean and the Limón-Coveñas, which pass through the departments of Nariño, Putumayo, Arauca, and Norte de Santander. Since January 1, Colombian state oil company Ecopetrol has reported 73 attacks on the oil infrastructure in those departments, with spills totaling 54,000 barrels of crude oil, according to General Ricardo Jiménez, National Army Chief of Operations. destruction of the youngest and newborn organisms; Special environmental contingency actions The Environmental Emergency Response Group (GAMA) and the Nariño Autonomous Regional Corporation (Corponariño) worked together to evaluate the environmentally significant maritime and coastal areas and affected fishing and tourist areas damaged by the spill. Since the Armed Forces teamed with government entities and the oil industry to coordinate responses to attacks on pipelines, such assaults have decreased significantly, according to Ministry of Defense statistics. Seventy-three attacks on Colombian pipelines using explosives occurred between January and August 2015, a significant decrease compared to the 109 such attacks that took place during the same time frame a year earlier. That in turn is down from 169 attacks in 2013. Additionally, terrorist attacks in general have also decreased in general since the Sword of Honor campaign was launched – going from 716 in 2012 to 382 between January and August of this year. It was the largest environmental disaster in the past decade according to Environmental Minister Gabriel Vallejo, and exacerbated the damage from a June 8 attack on the same pipeline that spilled 4,000 barrels of oil into the Caunapí and Rosario rivers. deaths of hundreds of animals from chronic poisoning and asphyxia; On top of those economic losses, attacks on oil-producing facilities greatly damage the environment. Due to southern Colombia’s high biodiversity, the real harm caused by spills in Nariño can only be evaluated months later, according to Luis Alberto Giraldo, Ministry of the Environment Director General of Territorial Environmental Regulations. “The project seeks support in the form of international cooperation,” Giraldo said. The Special Operations Center for Infrastructure Protection deployed specialized troops to remove anti-personnel mines allegedly set by the FARC after being informed by Cenit, the private company that operates the Trans-Andean Oil Pipeline, of the attack near the 72 kilometer marker on the Pasto-Tumaco road in Nariño. To contain the damage, the Ministry of Defense took a three-pronged approach, according to the Ministry of Defense Public Security and Infrastructure Bureau: In 2014, attacks on Ecopetrol caused the delay or lost production of 2.8 million barrels of crude oil, representing a loss of around 1.3 trillion pesos ($421 million), Gen. Jiménez added. destruction of food sources for higher species; injection of carcinogens into the food chain. To protect the country’s natural resources, the Ministry of the Environment is establishing an organization to study the impacts of environmental contamination on Colombia’s unique ecosystems. “We have put together an investigations group that includes universities and international organizations to have an economic dimension, allowing for a comprehensive study that discusses the effects on biodiversity, as well as the quantity and quality of the water resources,” Giraldo said. “Currently, we are using the department of Nariño as a pilot case, and the idea is to duplicate that model in other departments, keeping in mind the specific conditions in each and coordinating with government forces to carry it out.” Meanwhile, the Army provided security so officials could conduct tests for the environmental study, which included analyzing the impact the oil spill had on the coast. Economic losses
12SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr by: Leslie Tayne, Credit.comWe could all stand to be more frugal. After all, who doesn’t like to save money? But it isn’t always easy to curb our spending habits, and sometimes trying to find the best deal can feel like a chore. Unfortunately, entering the frugal lifestyle isn’t the easiest thing to do. Thankfully, there are some steps you can take to help make it a smoother transition. With that in mind, here’s my advice on how you can break into frugal living.1. Start SlowSometimes it can be difficult to make changes, and while some of us possess the fortitude to quit our bad habits cold turkey, the rest of us need to ease into transition. That’s why it’s best to take it slow when adopting the frugal lifestyle. Maybe you start by just cutting down on the number of times you go out to eat a week and cook a meal or two from home. Or you start to check for coupons online before you go out to shop. Taking baby steps towards frugality can help make it easier to stick with your new lifestyle. continue reading »